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Has Anyone Shifted From Cellcept To One Of The New Biologics? And, If So, What Was Your Experience.

A MGteam Member asked a question 💭
Cocoa, FL

I had acute onset of MG with serious exacerbations (on ventilator for a week) almost 4 years ago. After multiple rounds of plasma pheresis, steroids, etc., I was able to move to 2000 mg Cellcept daily as only meds and did quite well. Recently, however, I have noticed a return in fatigue and weakness and will be seeing my neurologist next week to consider altering medication. Thus my question about shift from Cellcept to one of the new biologics. Thank you.

November 9
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A MGteam Member

Switching from Cellcept (mycophenolate mofetil) to a biologic medication for myasthenia gravis (MG) is a significant decision that should be made in consultation with your neurologist. Here are some key points about biologics for MG:

Biologic Options
- Rituximab (Rituxan): Blocks B cells, reducing autoantibody Show Full Answer

Switching from Cellcept (mycophenolate mofetil) to a biologic medication for myasthenia gravis (MG) is a significant decision that should be made in consultation with your neurologist. Here are some key points about biologics for MG:

Biologic Options:
- Rituximab (Rituxan): Blocks B cells, reducing autoantibody production.
- Eculizumab (Soliris): Reduces inflammation in the neuromuscular junction.
- Ravulizumab (Ultomiris): Similar to eculizumab, but with a longer duration of action.
- Efgartigimod alfa-fcab (Vyvgart): An FcRn blocker that helps clear autoantibodies.
- Rozanolixizumab-noli (Rystiggo): Another FcRn blocker, administered subcutaneously.

Administration:
- Rituximab, Eculizumab, and Ravulizumab: Given by intravenous infusion.
- Efgartigimod: Infused by IV.
- Rozanolixizumab: Injected under the skin.

Considerations:
- Effectiveness: Biologics can be effective in reducing symptoms by targeting specific parts of the immune system.
- Side Effects: Each biologic has its own profile of potential side effects, which should be discussed with your doctor.
- Monitoring: Regular monitoring is essential to manage any adverse effects and to assess the effectiveness of the treatment.

Given your history of serious exacerbations and recent return of symptoms, discussing these options with your neurologist is a prudent step. They can provide personalized advice based on your medical history and current condition.

November 9

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