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Can You Switch From Ultromises To Yvvgart Without Any Problems

A MGteam Member asked a question 💭
Huntley, IL
January 4
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A MGteam Member

With Vyvgart, it works by targeting an antibody fragment. The antibody fragment is the protein they reference above.

Reference - first 2 describe protein, last describes Vyvgart mechanism of action

https://www.google.com/search?q=antibody+fragme...

https://www.sciencedirect.com/topics/engineerin....

Vyvgart mechanism of action reference: https://vyvgarthcp.com/gmg/about/moa?c3api=6025...

VYVGART, also known as efgartigimod alfa, the first and only IgG Fc-antibody fragment for the treatment of gMG in adult patients who are anti-AChR antibody positive1-3
Efgartigimod alfa is the Fc portion of an IgG antibody*—engineered for affinity to FcRn

Efgartigimod alfa targets and blocks FcRn to decrease IgG antibodies, including AChR autoantibodies, resulting in a decrease of pathogenic activity

I hope this wasn’t overly technical. I hope helpful

https://www.sciencedirect.com/topics/engineering/antibody-fragment
Mechanism of Action | VYVGART® & VYVGART® Hytrulo
Mechanism of Action | VYVGART® & VYVGART® Hytrulo
Google Search
7 days ago
A MGteam Member

Switching from Ultomiris to Vyvgart for myasthenia gravis should be done under the guidance of a healthcare professional. Both medications work differently—Ultomiris is a monoclonal antibody, while Vyvgart targets a specific protein to reduce harmful antibodies. Transitioning may require careful planning to avoid gaps in Show Full Answer

Switching from Ultomiris to Vyvgart for myasthenia gravis should be done under the guidance of a healthcare professional. Both medications work differently—Ultomiris is a monoclonal antibody, while Vyvgart targets a specific protein to reduce harmful antibodies. Transitioning may require careful planning to avoid gaps in treatment or adverse effects. Always consult your doctor for a personalized plan.

January 4

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