Ann, I am so sorry. I get so frustrated with this horrible disorder and the treatments that aren't as effective as I'd hoped for.

I used to take magnesium until I learned it was contraindicated formyathenics
I take only 1/2 (of 60 mg pill 3-4 ax day potassium and stretching walks and Epsom salt baths help

Ann, I am awake right now because of painful spasms in my feet and legs These occur during the night and during the day. Before my diagnosis of MG, my neurologist thought I had restless leg syndrome. The two neurologists that I have seen over the years have said the spasms are not related to MG. I feel they are, and it make sense. Our muscles fatigue easily, and that is what causes the spasms, so I would say yes to your question.

I have to limit my Mestinon dosing because it causes lower extremity pain at night, for me anyway. I don’t take it after 3pm. It doesn’t really do much anyway. This dreadful disorder and the treatments are SO different for everyone!

Ann, I take the same dosage four times a day, and the spasms continue. The worse ones are the ones that spasm up the fronts of my legs where the skin is tighter. I have had them go on for hours at a time. Sometimes it is because I pushed myself too hard during the day, but not always. I am a firm believer that it is related to the MG. They occur during the day too, and when they do, I know I am going to have a really bad night. Someone said online once to eat a pickle or drink pickle juice. I have done that too! I am on potassium for my heart issues, so it is not potassium levels. YOU ARE NOT ALONE! Hang in there!